Quinolines and derivatives
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Filtered Search Results
eMolecules 16959-62-9 | methyl indolizine-2-carboxylate | Pharmablock | MFCD13178636 | 175.187 | C10H9NO2 | 97.000 | COC(=O)c1cc2ccccn2c1 | 50mg | 788527013
methyl indolizine-2-carboxylate | Pharmablock | 16959-62-9 | MFCD13178636 | 175.187 | C10H9NO2 | 97.000 | COC(=O)c1cc2ccccn2c1 | 50mg | 788527013
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Medchemexpress LLC Lodoxamide (U-42585E free acid) | 53882-12-5 | 98.1% | C11H6ClN3O6 | 200 MG
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Lodoxamide (U-42585E free acid) is an antiallergic compound that acts as a mast-cell stabilizer, used for the treatment of asthma and allergic conjunctivitis.
- Inhibits histamine release and calcium influx in mast cells.
- Reduces chemotactic response of eosinophils to fMLP and IL-5.
- Inhibits eosinophil peroxidase release after IgA-dependent activation.
- Demonstrates cromolyn-like activity in mast cell assays and antigen-sensitized rhesus monkeys.
- Inhibits increased respiratory frequency and decreased tidal volume induced by antigen challenge.
- Reduces lung reperfusion injury in organ preservation solutions.
- Improves daytime breathing difficulty, cough, sputum, and sleep in patients.
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eMolecules 939-16-2 | 3-Bromo-2-quinolinol | Combi-Blocks | MFCD00234482 | 224.057 | C9H6BrNO | 96.000 | Oc1nc2ccccc2cc1Br | 1g | 457920314
3-Bromo-2-quinolinol | Combi-Blocks | 939-16-2 | MFCD00234482 | 224.057 | C9H6BrNO | 96.000 | Oc1nc2ccccc2cc1Br | 1g | 457920314
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Medchemexpress LLC B7-H2/ICOSLG protein, cynomolgus | >95.0% | 20 UG
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B7-H2/ICOSLG protein (cynomolgus) is a recombinant extracellular domain of the ICOS ligand produced in HEK293 mammalian cells with a C-terminal His tag. Supplied lyophilized from PBS (pH 7.4), the protein is intended for immunology and receptor-ligand interaction studies and is characterized by low endotoxin and a defined amino acid range (M1-T256).
- Recombinant protein expressed in HEK293 mammalian cells.
- C-terminal His tag for purification and detection.
- Amino acid range M1-T256 corresponding to the extracellular domain.
- Observed molecular weight 50-70 kDa.
- Endotoxin <1 EU/μg (LAL method).
- Lyophilized formulation from PBS, pH 7.4; recommend aliquoting for storage.
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Apexbio Technology LLC LY2940680 1258861-20-9 200mg
LY2940680 (CAS 1258861-20-9) is a selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane G protein-coupled receptor involved in regulating Hedgehog (Hh) signalling LY2940680 binds primarily to the extracellular loops of Smo distinguishing it from previously described inhibitors such as SANT-1 which bind to the transmembrane domain By blocking Smo function LY2940680 suppresses downstream Hh pathway activation resulting in reduced cell proliferation observed in cell lines with Smo mutations or resistance to vismodegib Investigations of LY2940680 in basal cell carcinoma and medulloblastoma highlight its potential utility as a single-agent therapeutic targeting cancer stem cell populations
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Apexbio Technology LLC Leukadherin 1 344897-95-6 200mg
Leukadherin 1 (CAS 344897-95-6) is a small molecule agonist of the integrin CD11b/CD18 a cell surface adhesion receptor predominantly expressed on innate immune cells By activating CD11b/CD18 Leukadherin 1 enhances cell adhesion to fibrinogen with an EC50 of 4 M and increases CD11b/CD18-mediated adhesion to ICAM-1 In cellular models such as K562 cells it promotes membrane tether formation facilitating integrin-ligand interactions In vivo Leukadherin 1 reduces neutrophil accumulation in mouse models of acute peritonitis and decreases leukocyte infiltration and tissue injury in models of kidney transplantation and hyperoxia-induced lung injury This compound serves as a research tool for investigating integrin-mediated leukocyte functions and inflammatory processes
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Medchemexpress LLC Sulfo-Cy5 maleimide | 2130955-10-9 | 92.9% | 764.91 | C38H44N4O9S2 | 10 MG
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Sulfo-Cy5 maleimide is a sulfonated Cyanine-5 maleimide fluorescent dye that selectively labels thiol groups via a stable thioether linkage, enabling covalent protein and antibody conjugation for imaging and assays. It is water-soluble and optimized for far-red fluorescence detection in biochemical and cell-based applications.
- Thiol-selective maleimide for covalent protein labeling.
- Far-red Cy5 fluorescence suitable for imaging and detection.
- Water-soluble sulfonated structure improves aqueous compatibility.
- Soluble in DMSO at about 125 mg/mL (163.42 mM); ultrasonic assistance recommended; use freshly opened DMSO.
- Purity approximately 92.9% and molecular weight ≈764.91 g/mol.
- Store protected from light at 4°C; in solution keep at -80°C (6 months) or -20°C (1 month).
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Apexbio Technology LLC Amsacrine 51264-14-3 200mg
Amsacrine (CAS 51264-14-3) also known as m-AMSA is a small-molecule inhibitor of DNA topoisomerase II It is widely used as an antineoplastic agent in biomedical research particularly for investigating the treatment of lymphomas and acute leukemias Amsacrine exhibits cytotoxic effects across various cancer cell lines with reported IC50 values of 190 2 27 4 ng/ml 46 1 3 9 ng/ml and 22 6 3 1 ng/ml in HT1376 RT112 and RT4 bladder cancer cells and 11 8 2 0 ng/ml 5 0 0 4 ng/ml and 11 7 1 5 ng/ml in the 833K Susa and GH testicular cancer cell lines respectively Testicular cancer cell lines display greater sensitivity to Amsacrine-induced inhibition than bladder cancer cell lines This compound is valuable for studying DNA damage mechanisms and the cellular response to topoisomerase II inhibition
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TARGETMOL CHEMICALS INC YKL-06-061 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3 respectively. purity: 99%
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Medchemexpress LLC Z-Leu-Leu-Leu-al | 133407-82-6 | MFCD00674886 | 99.9% | 475.6 | 200 MG
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MG-132 is a potent and reversible proteasome inhibitor with an IC50 of 100 nM. It also acts as a calpain inhibitor with an IC50 of 1.2 μM. It effectively blocks the proteolytic activity of the 26S proteasome complex, acts as an autophagy activator, and induces apoptosis.
- Potent and reversible proteasome inhibitor
- Blocks proteolytic activity of the 26S proteasome complex
- Acts as an autophagy activator
- Induces apoptosis
- Calpain inhibitor
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Medchemexpress LLC Sulfo-Cy3 azide | 1801695-56-6 | MFCD30527437 | 99.6% | 806.97 | C35H46N6O10S3 | 10 MG
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Sulfo-Cy3 Azide is a water-soluble Cy3 fluorescent dye bearing an azide functional group for bioorthogonal click chemistry. It is designed for labeling sensitive biomolecules, such as proteins, via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted azide-alkyne cycloaddition (SPAAC). The dye exhibits excitation/emission around 550/570 nm and is supplied in research pack sizes.
- Water-soluble cyanine dye suitable for aqueous labeling reactions.
- Azide functional group enables CuAAC and SPAAC click chemistry.
- Excitation/emission approximately 550/570 nm for bright fluorescence.
- Soluble in DMSO at 50 mg/mL (requires sonication; use fresh DMSO).
- High purity suitable for research applications.
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Apexbio Technology LLC Sparteine 492-08-0 200mg
Sparteine (CAS 492-08-0) is a naturally occurring alkaloid recognized for its activity as a ganglionic blocker It acts by competitively inhibiting neuronal nicotinic acetylcholine receptors thereby modulating synaptic transmission within the nervous system Owing to this specific mechanism sparteine is widely employed in neurobiological and pharmacological research to investigate neuronal signaling pathways and to elucidate mechanisms involved in central nervous system disorders Its use facilitates the exploration of neurotransmitter regulation and receptor function in experimental models
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Cayman Chemical DImethyl sulfon 5g
An organic sulfur derivative described to have anti-inflammatory and analgesic properties; commonly found as an adulterant in methamphetamine samples
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Apexbio Technology LLC D-Pantothenate sodium 867-81-2 200mg
D-Pantothenate sodium (CAS 867-81-2) is a water-soluble small molecule that serves as a biosynthetic precursor to coenzyme A (CoA) Through its conversion to CoA D-pantothenate sodium participates in vital cellular processes involving the metabolism of carbohydrates lipids proteins and nucleic acids It modulates metabolic pathways by influencing the activity of enzymes and associated signaling networks thereby contributing to cellular metabolic regulation This compound is frequently employed in studies investigating cellular metabolism disease models related to metabolic dysfunction and the biochemical mechanisms underlying enzyme-catalyzed reactions
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eMolecules 252917-06-9 | CHIR-99021 | TargetMol | MFCD11846251 | 465.340 | C22H18Cl2N8 | 0.000 | Cc1c[nH]c(n1)-c1cnc(NCCNc2ccc(cn2)C#N)nc1-c1ccc(Cl)cc1Cl | 200mg | 845737039
CHIR-99021 | TargetMol | 252917-06-9 | MFCD11846251 | 465.340 | C22H18Cl2N8 | 0.000 | Cc1c[nH]c(n1)-c1cnc(NCCNc2ccc(cn2)C#N)nc1-c1ccc(Cl)cc1Cl | 200mg | 845737039
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